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Effect of SIAH2 knockdown on tamoxifen sensitivity. (A) MCF-7 and MDA-MB-231 cell counts with and without SIAH2 knockdown shown as ratios following treatment with tamoxifen 1 µM. siSIAH2 knockdown followed by tamoxifen treatment showed decreased sensitivity. (B) Western blot confirming knockdown of SIAH2 and subsequent effect on ER-α.
