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. Author manuscript; available in PMC: 2015 Jul 1.
Published in final edited form as: J Surg Res. 2014 Feb 19;190(1):203–209. doi: 10.1016/j.jss.2014.02.018

Fig. 4.

Fig. 4

Effect of SIAH2 knockdown on ER-α expression. (A) MCF-7 cells treated with tamoxifen had induction of ER-α and SIAH2. Treatment with β-estradiol resulted in downregulation of ER-α, with little change in SIAH2 expression. (B) Selective SIAH2 knockdown with siRNA in MCF-7 cells resulted in downregulation of ER-α by Western blot analysis and quantitative real-time polymerase chain reaction. (C) Selective knockdown of ER-α resulted in downregulation of ER-α, but with minimal change in SIAH2 (**P < 0.005).