Table 4.
Effect of FH on atrophy rates in ApoE 3/3 homozygotes.
| Primary regions | FH rate | Cohen's D for FH effect | FH p-value |
|---|---|---|---|
| Hippocampus.total.vol | 0.002 | 0.07 | 0.54939 |
| Amygdala.Total.Vol | −0.009 | −0.17 | 0.14095 |
| Entorhinal.cortex.TA | −0.001 | −0.04 | 0.70974 |
| Cerebral.cortex.total.vol | 0.001 | 0.04 | 0.72922 |
| Exploratory regions | |||
| Parahippocampal.TA | 0.002 | 0.06 | 0.61137 |
| Pericalcarine.TA | −0.005 | −0.22 | 0.0535 |
| Postcentral.TA | −0.001 | −0.03 | 0.77311 |
| Posterior.cingulate.TA | 0.002 | 0.1 | 0.3911 |
| Precentral.TA | −0.004 | −0.12 | 0.29272 |
| Precuneus.TA | 0.002 | 0.1 | 0.39153 |
| Superior.parietal.TA | −0.001 | −0.04 | 0.72119 |
| Superior.temporal.TA | 0.002 | 0.09 | 0.4295 |
| Temporal.pole.TA | −0.002 | −0.06 | 0.57661 |
| Transverse.temporal.TA | 0.005 | 0.13 | 0.26851 |
| Cerebellar.cortex.total.vol | 0.001 | 0.05 | 0.68839 |
| Cerebellar.WM.total.volume | −0.002 | −0.06 | 0.60951 |
| Fusiform.gyrus.TA | −0.003 | −0.11 | 0.35543 |
| Inferior.parietal.TA | 0 | 0.01 | 0.9105 |
| Inferior.temporal.TA | −0.003 | −0.13 | 0.27452 |
| Middle.temporal.TA | −0.001 | −0.06 | 0.59783 |
FH rate is the additional effect of FH after adjusting for age and gender. The estimated rate effects are in units of percent increase in log volume per year: a value of 1.00 (approximately) represents a 1% increase in volume per year. Negative values indicate atrophy. The amygdala is the only region that comes close to significance among the predicted regions.