Fig. A.2.

Bar plots showing the Hellinger distance-based variances before and after normalization in the simulation studies (shorter bars show more similarity in intensity distribution across images). Each plot corresponds to a different set of parameters (shown in Table 1) and each bar represents a single tissue class on a particular modality after a normalization (indicated by color, with green indicating raw images and orange indicating white stripe normalized images). Note that the method performs well throughout, but shows least benefit in setting 7 for which the variability in means across tissue classes is most similar to the variability within tissue classes.