FIG. 2.

Captopril attenuates high-dose HBOC-induced vasospasm and cardiac function impairment. (A) Representative coronary angiograms acquired at baseline and after intracoronary infusion of HBOC. Red arrow heads indicate constricted segments. (B, C) The percentage of change in coronary artery luminal diameter and rate of vasoconstriction. Negative values for coronary artery changes indicate vasoconstriction. (D) Representative M-Mode echocardiogram and speckle tracking images after intracoronary infusion of HBOC. (E, F) Quantitative analysis of LVEF and LVLS. Values are presented as mean±SD (n=5 per group). ***p<0.001 versus the 0.1%HBOC group; ^#p<0.05 and ^##p<0.01 versus the 3%HBOC group. ACEI in the figure indicates ACE inhibitor captopril. To see this illustration in color, the reader is referred to the web version of this article at www.liebertpub.com/ars