Table 1.
Comparison of the TNFA-308G>A Allele and Genotype Frequencies between Peptic Ulcer Patients and Healthy Individuals and between Helicobacter pylori-Infected and -Uninfected Peptic Ulcer Patients
| Peptic ulcer case (n=177) | Healthy individual (n=248) | p-value | OR | 95% CI | |
|---|---|---|---|---|---|
| GG | 121 (68.4) | 172 (69.4) | 0.8775 | 1.00 | - |
| GA | 54 (30.5) | 72 (29.0) | 1.02 | 0.98–1.53 | |
| AA | 2 (1.1) | 4 (1.6) | 1.04 | 0.46–2.35 | |
| G | 296 (83.6) | 416 (83.9) | 0.9208 | - | - |
| A | 58 (16.4) | 80 (16.1) | - | - | |
| HWE p-value | 0.3200 | 0.5878 | |||
|
| |||||
| All peptic ulcer cases | |||||
|
|
|||||
| Infected (n=86) | Uninfected (n=91) | ||||
|
| |||||
| GG | 58 (67.4) | 63 (69.2) | 0.7981 | 1.00 | - |
| GA or AA | 28 (32.6) | 28 (30.8) | 1.09 | 0.57–2.06 | |
| G | 144 (83.7) | 152 (83.5) | 0.9586 | - | - |
| A | 28 (16.3) | 30 (16.7) | - | - | |
| HWE p-value | 0.2066 | 0.9802 | |||
|
| |||||
| Female peptic ulcer case | |||||
|
|
|||||
| Infected (n=54) | Uninfected (n=57) | ||||
|
| |||||
| GG | 33 (61.1) | 42 (73.7) | 0.1573 | 1.00 | - |
| GA or AA | 21 (38.9) | 15 (25.3) | 1.78 | 0.59–5.39 | |
| G | 87 (80.6) | 98 (86.0) | 0.2797 | - | - |
| A | 21 (19.4) | 16 (14.0) | - | - | |
| HWE p-value | 0.2171 | 1.000 | |||
|
| |||||
| Male peptic ulcer case | |||||
|
|
|||||
| Infected (n=32) | Uninfected (n=34) | ||||
|
| |||||
| GG | 25 (78.1) | 21 (61.8) | 0.1515 | 1.00 | - |
| GA or AA | 7 (21.9) | 13 (38.2) | 0.45 | 0.02–10.22 | |
| G | 57 (89.1) | 54 (79.4) | 0.1312 | - | - |
| A | 7 (10.9) | 14 (20.6) | - | - | |
| HWE p-value | 0.9200 | 0.9556 | |||
Values are presented as number (%).
OR, odds ratio; CI, confidence interval; HWE, Hardy-Weinberg equilibrium.