Table 2.
Comparison of the TNFA-1031T>C Allele and Genotype Frequencies between Peptic Ulcer Patients and Healthy Individuals and between Helicobacter pylori-Infected and -Uninfected Peptic Ulcer Patients
| Peptic ulcer case (n=177) | Healthy individual (n=248) | p-value | OR | 95% CI | |
|---|---|---|---|---|---|
| TT | 113 (63.8) | 167 (67.3) | 0. 9663 | 1.00 | - |
| CT | 61 (34.5) | 76 (30.6) | 1.02 | 0.98–1.53 | |
| CC | 3 (1.7) | 5 (2.0) | 1.04 | 0.46–2.35 | |
| T | 287 (81.1) | 410 (82.7) | 0.5525 | - | - |
| C | 67 (18.9) | 86 (17.3) | - | - | |
| HWE p-value | 0.2622 | 0.6228 | |||
|
| |||||
| All peptic ulcer case | |||||
|
|
|||||
| Infected (n=86) | Uninfected (n=91) | ||||
|
| |||||
| TT | 54 (62.8) | 59 (64.8) | 0.7772 | 1.00 | - |
| CT or CC | 32 (37.2) | 32 (35.2) | 1.09 | 0.59–2.03 | |
| T | 139 (80.8) | 148 (81.3) | 0.9036 | - | - |
| C | 33 (19.2) | 34 (18.7) | - | - | |
| HWE p-value | 0.3684 | 0.7816 | |||
|
| |||||
| Female peptic ulcer case | |||||
|
|
|||||
| Infected (n=54) | Uninfected (n=57) | ||||
|
| |||||
| TT | 33 (61.1) | 35 (61.4) | 0.9748 | 1.00 | - |
| CT or CC | 21 (38.9) | 22 (38.6) | 1.09 | 0.59–2.03 | |
| T | 86 (79.6) | 96 (79.8) | 0.2797 | - | - |
| C | 22 (20.4) | 23 (20.2) | - | - | |
| HWE p-value | 0.6867 | 0.5982 | |||
|
| |||||
| Male peptic ulcer case | |||||
|
|
|||||
| Infected (n=32) | Uninfected (n=34) | ||||
|
| |||||
| TT | 21 (65.6) | 24 (70.6) | 0.6653 | 1.00 | - |
| CT or CC | 11 (34.4) | 10 (29.4) | 1.26 | 0.42–3.77 | |
| T | 53 (82.8) | 57 (83.8) | 0.8762 | - | - |
| C | 11 (17.2) | 11 (16.2) | - | - | |
| HWE p-value | 0.4748 | 1.000 | |||
Values are presented as number (%).
OR, odds ratio; CI, confidence interval; HWE, Hardy-Weinberg equilibrium.