Table 2.
Univariate and Multivariate Logistic Regression Models for Predicting Early Tumor Recurrence in 259 Patients with Hepatocellular Carcinomas
| Variable | Univariate model | Multivariate model | ||||
|---|---|---|---|---|---|---|
|
|
|
|||||
| Coefficient | OR (95% CI) | p-value | Coefficient | OR (95% CI) | p-value | |
| Age (≤55 vs >55), yr | 0.210 | 1.23 (0.75–2.03) | 0.410 | - | - | - |
| Gender (female vs male) | 0.097 | 1.10 (0.59–2.07) | 0.762 | - | - | - |
| Tumor size (≤5.0 vs >5.0), cm | 0.900 | 2.46 (1.45–4.17) | 0.001 | 0.198 | 1.22 (0.62–2.41) | 0.568 |
| Edmondson grade (I+II vs III) | 0.981 | 2.67 (1.41–5.06) | 0.003 | 0.504 | 1.66 (0.78–3.52) | 0.190 |
| Microvascular invasion (no vs yes) | 1.343 | 3.83 (2.28–6.43) | <0.001 | 0.430 | 1.54 (0.81–2.94) | 0.192 |
| Major portal vein invasion (no vs yes) | 2.309 | 10.06 (1.28–79.13) | 0.028 | −0.188 | 0.83 (0.081–8.48) | 0.874 |
| Intrahepatic metastasis (no vs yes) | 2.810 | 16.61 (6.38–43.21) | <0.001 | 2.408 | 11.11 (3.52–35.05) | <0.001 |
| Multicentric occurrence (no vs yes) | 0.555 | 1.74 (0.51–5.94) | 0.375 | - | - | - |
| AJCC T-stage (1 vs 2+3+4) | 1.414 | 4.11 (2.44–6.94) | <0.001 | - | - | - |
| BCLC stage (0+A vs B+C) | 1.322 | 3.75 (2.24–6.32) | <0.001 | - | - | - |
| Albumin level (>3.5 vs ≤3.5), g/dL | 0.981 | 2.67 (1.09–6.55) | 0.032 | 0.816 | 2.26 (0.83–6.19) | 0.113 |
| AFP level (≤200 vs >200), ng/mL* | 0.444 | 1.56 (0.93–2.61) | 0.092 | - | - | - |
| Etiology (nonviral vs viral) | 0.991 | 2.70 (1.28–5.66) | 0.009 | 0.847 | 2.33 (0.99–5.53) | 0.054 |
| Liver cirrhosis (no vs yes) | 0.357 | 1.43 (0.88–2.34) | 0.154 | - | - | - |
| RRM2 expression (low vs high) | 0.979 | 2.66 (1.39–5.09) | 0.003 | 0.808 | 2.24 (1.04–4.86) | 0.040 |
OR, odds ratio; CI, confidence interval; AJCC, American Joint Committee on Cancer; BCLC, Barcelona Clinic Liver Cancer; AFP, α-fetoprotein; RRM2, ribonucleotide reductase subunit M2.
*
Data for 10 patients were unavailable.