Table 4.

Multivariate Analyses of Recurrence-Free Survival and Disease-Specific Survival in 259 Patients with Hepatocellular Carcinomas

Variable	Recurrence-free survival		Disease-specific survival
	HR (95% CI)	p-value	HR (95% CI)	p-value
Tumor size (≤5.0 vs >5.0), cm	1.16 (0.82–1.66)	0.407	1.38 (0.88–2.16)	0.163
Edmondson grade (I+II vs III)	1.16 (0.80–1.69)	0.427	1.09 (0.68–1.74)	0.721
Microvascular invasion (no vs yes)	1.35 (0.93–1.97)	0.114	1.47 (0.84–2.57)	0.173
Major portal vein invasion (no vs yes)	1.01 (0.50–2.03)	0.988	1.54 (0.75–3.19)	0.244
Intrahepatic metastasis (no vs yes)	3.07 (2.04–4.64)	<0.001	3.71 (2.21–6.23)	<0.001
Albumin level (>3.5 vs ≤3.5), g/dL	1.58 (1.01–2.48)	0.046	2.07 (1.20–3.56)	0.009
Etiology (nonviral vs viral)	1.59 (0.94–2.68)	0.082	-	-
Liver cirrhosis (no vs yes)	1.32 (0.96–1.82)	0.092	-	-
RRM2 expression (low vs high)	1.36 (0.90–2.05)	0.147	2.73 (1.30–5.70)	0.008

HR, hazard ratio; CI, confidence interval; RRM2, ribonucleotide reductase subunit M2.