Table 3.

Connectivity prediction of behavioral response results.

					Milnacipran period		Placebo period
Pre-tx connectivity (seed to region)	Size (voxels)	Coordinates (MNI)			r value	p value	r value	p value
		x	y	z
					BPI Sev
R PAG–R midIC	21	34	−2	16	0.885	<0.001	−0.216	0.440
R DLPFC–L IPL	152	−40	−44	46	0.873	<0.001	0.030	0.917
L amyg–PCC/precuneus	232	−4	−64	10	−0.916	<0.001	−0.389	0.152
					BPI Int
pgACC–R IC	133	36	−6	10	0.900	<0.001	0.082	0.771
pgACC–L DLPFC	95	−52	12	34	-0.050	0.859	0.869	<0.001

Table 3 displays significant results from the pre-treatment scan connectivity prediction analyses for clinical and experimental pain changes to treatment by period. Both milnacipran and placebo period statistics are displayed, with results found to be significant in bold. Statistics from the placebo period are provided to demonstrate no significant effect. ACC = anterior cingulate cortex, pgACC = pregenual anterior cingulate cortex, BPI Int = Short Form of the Brief Pain Inventory–Interference score, BPI Sev = Short Form of the Brief Pain Inventory–Severity score; DLPFC = dorsolateral prefrontal cortex, IC = insular cortex, IPL = inferior parietal lobule, L = left, MNI = Montreal Neurological Institute, PAG = periaqueductal gray, Pre-tx = pre-treatment, R = right.