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. 2014 Jul 12;6:296–306. doi: 10.1016/j.nicl.2014.06.016

Table 3.

Detailed clinical characteristics of patients with atypical language lateralizationa.

Patient number Broca laterality index Wernicke laterality index Cerebellar laterality index Handedness
L = left
R = right
Age at fMRI
(years)
Seizure onset (years) Seizure focus Lesion location Lesion type Language
(scaled scores)b
Broca Right patients
6 –0.36 0.05 0.03 R 14 0.25 Left parietal Left parietal occipital Cortical dysplasia 6
8 –1.00 –1.00 0.82 R 12 8 Left parietal Normal Unknown Unknown
13 –0.48 –1.00 –0.01 R 15 0.003 Left parietal Left frontal parietal; right frontal Perinatal stroke Unknown
25 –0.90 –1.00 1.00 L 10 8 Left frontal Left frontal temporal Perinatal stroke 7
37 –1.00 0.26 n/ac R 12 7 Left frontal Normal Cortical dysplasia 10
38 –0.28 –0.74 0.27 L 16 1 Left frontal Left frontal parietal occipital Pachygyria, polymicrogyria 5
49 –0.50 1.00 1.00 R 16 7 Left temporal Left temporal Tumor 9
60 –0.25 –0.98 0.60 R 11 3 Left temporal Left temporal Polymicrogyria 4
Additional atypical patients
5 0.25 0.16 –0.48 R 14 7 Left temporal Left temporal Unknown 8
40 –0.10 0.17 0.42 R 10 0.003 Left temporal Left temporal Tumor + cortical dysplasia 7
43 0.84 0.13 –0.38 R 10 9 Left temporal Left & right temporal Cortical dysplasia Unknown
51 0.22 0.89 0.98 R 14 7 Left frontal Normal Unknown 9
55 0.46 0.21 0.19 R 16 15 Left & right temporal Left frontal Vascular malformation 10
a

Atypical language defined as any patient who does not have left lateralization of Broca's and Wernicke's areas paired with right lateralization of the cerebellum.

b

Language function of patients with right or mixed cerebral language dominance was assessed using an average of the scaled scores obtained on the Vocabulary, Similarities, and Comprehension subtests of the Weschler Intelligence Scale for Children (WISC) or Weschler Adult Intelligence Scale (WAIS) depending on age of the child being tested.

c

Not applicable (n/a) as patient did not have above-threshold cerebellar language task activation.