Table 1.
Nuclear Receptors and G-Protein Coupled Receptors Activated by Different Bile Acids
| Nuclear Receptor | Bile Acid Agonist | References |
|---|---|---|
| Farnasoid X Receptor (FXR) | CDCA >LCA = DCA>CA | reviewed by 16 |
| Pregnane-activated receptor (PXR) | LCA>DCA>CA | reviewed by 16 |
| Vitamin D receptor | 3-oxo-LCA>LCA>DCA>CA | 32 |
|
| ||
| G-Protein Coupled Receptors | ||
| TGR-5 | DCA>LCA>CDCA>CA | 33 |
| Sphingosine-1-phosphate Receptor 2 (S1PR2) |
Taurine or Glycine Conjugated Bile Acids |
34 |
| (M2,3) Muscarinic receptors | T-LCA>T-DCA>T-CA | 35-37 |