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. 2014 Oct 31;5:535. doi: 10.3389/fimmu.2014.00535

Figure 1.

Figure 1

The development of antibody responses. Specific antibody responses develop in secondary lymphoid tissues. B-cells responding to T-dependent and T-independent antigens migrate through the T-zone before producing antibody through the germinal center (GC) or extrafollicular (EF) pathway. Tfh cell – T follicular helper.