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. Author manuscript; available in PMC: 2015 Apr 29.
Published in final edited form as: Nature. 2014 Oct 30;514(7524):591–596. doi: 10.1038/nature13890

Figure 1. Crystal structure of PRC1 ubiquitylation module-nucleosome core particle complex.

Figure 1

a, View of the complex looking down on the DNA superhelical axis. b, Orthogonal view of the complex with proximal and distal halves of the structure indicated. c, Zoomed view demonstrating Ring1B/Bmi1 heterodimer positioning UbcH5c active site Cys85 over the H2A C-terminal tail near the H2A Lys119 Cα atom (orange sphere). Crystals contain the minimal RING heterodimer Ring1B(2-116)/Bmi1(2-109).