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. Author manuscript; available in PMC: 2015 Apr 29.
Published in final edited form as: Nature. 2014 Oct 30;514(7524):591–596. doi: 10.1038/nature13890

Extended Data Figure 4. Chromatin factors use an arginine-anchor to bind the H2A/H2B acidic patch.

Extended Data Figure 4

Identical views of a, E3 ligase Ring1B (blue), b, viral LANA peptide (purple, PDB ID 1ZLA27), c, chromatin factor RCC1 (purple, PDB ID 3MVD28), d, centromeric protein CENP-C (green, PDB ID 4INM30), and e, silencing protein Sir3 (brown, PDB ID 3TU429) bound the acidic patch. Conserved arginine is shown in space-filling representation. Other arginines involved in binding are shown as sticks. UbcH5c and the Ring1B loop between residues 81 and 98 are not shown for figure clarity.