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. 2014 Oct 31;5:427. doi: 10.3389/fphys.2014.00427

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Copyright © 2014 Mazzatenta, Marconi, Zara, Cataldi, Porzionato and Di Giulio.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Immunohistochemistry detection of galanin expression in human carotid body, in young (A,B) and old (C,D) healthy subjects, compared to drug-addicted subjects (E,F). With the drug addiction, note the scarce labeling that is higher than for the old healthy subjects, which shows a dramatic effect of the disorganization in the sensory region with the reduction of the neuronal-like cells and increases in the connective tissue fibers, seen as interlobular (left panel) and intralobular at higher magnification (right panel).