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. 2014 Oct 31;5:427. doi: 10.3389/fphys.2014.00427

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Copyright © 2014 Mazzatenta, Marconi, Zara, Cataldi, Porzionato and Di Giulio.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Morphometric analysis of the positive areas for galanin and HIF in the human carotid body sections from the healthy young and old subjects, compared to the drug-addicted subjects, performed on anti-galanin immunohistochemistry labeling. One-Way ANOVA demonstrates a significant decrease in galanin expression on aging, and higher levels in drug-addicted subjects (p < 0.001); conversely, there is a significant increase in HIF expression upon aging, that is greater for the drug-addicted subjects.