Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2014 Oct 31;5:413. doi: 10.3389/fphys.2014.00413

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2014 Staiculescu, Ramirez-Perez, Castorena-Gonzalez, Hong, Sun, Meininger and Martinez-Lemus.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

LPA-induced FN-integrin adhesion is decreased by blockade of LPA receptors LPAR1 and LPAR3. (A) LPA treatment (2 μM) for 2 h in the presence of Ki16425 (10 μM, n = 40) results in a 40% decrease in FN-integrin adhesion compared with the cells treated with LPA alone (n = 40). (B) Incubation of VSMC with LPA (2 μM) in the presence of DMSO (n = 39), the solvent for Ki16425, does not result in a change in FN-integrin adhesion compared with VSMC treated with LPA (2 μM) alone (n = 39). (C) Ki16425 (10 μM, n = 40) alone does not change significantly the integrin-FN adhesion of VSMC compared with untreated controls (n = 40). Data are mean ± s.e.m. ^*P < 0.05 vs. LPA alone.