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. 2014 Oct 31;5:413. doi: 10.3389/fphys.2014.00413

Figure 4.

Figure 4

LPA-induced ROS production is inhibited by blockade of LPAR1 and LPAR3. (A) Representative images of DHE-dependent fluorescence in VSMC exposed to 2 μM LPA (left) or vehicle control (right) for 2 h. (B) In VSMC exposed for 2 h to DHE (10 μM, n = 5) alone the fluorescence intensity is 45% lower than in VSMC incubated 2 h with LPA + DHE (n = 5). (C) Representative images of DHE-dependent fluorescence in VSMC exposed LPA alone (left) or LPA + Ki16425 (right). (D) VSMC exposure to both Ki16425 (10 μM, n = 5) and LPA reduced the increase in fluorescence induced by LPA alone by 45% (n = 5). Data were normalized to the average intensity values of LPA treatment. Bar size = 20 μm. Data are means ± s.e.m. *P < 0.05 vs. LPA + DHE.