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. Author manuscript; available in PMC: 2015 Jan 1.
Published in final edited form as: Nat Chem. 2014 Jun 1;6(7):635–643. doi: 10.1038/nchem.1963

Figure 4. Oleanolic acid derivative 18, which lacks both the C4-aldehyde substituent and C16-alcohol in the triterpene domain of QS-21, exhibits poor adjuvant activity in a preclinical mouse vaccination model.

Figure 4

Biological evaluation of oleanolic acid derivative 18 (SQS-1-7-5-18) with a three-component vaccine for (a) anti-KLH titers (IgG), (b) anti-MUC1 titers (IgG) and (c) anti-OVA titers (IgG), indicating attenuated adjuvant activity; horizontal bars indicate median titers; statistical significance compared to no-adjuvant control: * = p ≤ 0.05, ** = p < 0.01, *** = p < 0.001. (d) Toxicity assessment based on median percent weight, indicating low toxicity of 18 (SQS-1-7-5-18); error bars indicate maximum and minimum values for five mice.