. Author manuscript; available in PMC: 2015 Sep 1.

Published in final edited form as: J Am Stat Assoc. 2014 Apr 1;109(507):931–943. doi: 10.1080/01621459.2014.904789

Table 5.

Simulation study comparing U^opt + Acc and U^opt + Acc + AR₂ for a hypothetical trial where the acceptability limits π_H(x) ≤ .25 and π_S(x) ≥ 0.40 are appropriate.

		Scenario

Design		1	2	3	4	5	6	7
U^opt + Acc	R_select	96	93	99	91	82	61	65
	R_treat	96	92	98	90	73	53	50
	% None	0	0	0	0	0	0	2
	# Pats	60.0	60.0	60.0	60.0	60.0	60.0	59.3
	# HEM	4.1	2.7	2.4	2.8	2.2	2.5	2.8
	# Succ	36.7	40.7	39.4	33.2	29.0	22.9	21.7

U^opt + Acc + AR₂	R_select	95	93	95	96	91	84	90
	R_treat	92	83	88	88	76	67	66
	% None	0	0	0	0	0	0	1
	# Pats	60.0	60.0	60.0	60.0	59.9	59.9	59.5
	# HEM	5.7	4.6	2.7	3.7	2.6	2.7	3.1
	# Succ	36.7	39.1	36.7	35.4	32.6	29.0	27.6