Table 1. Fixed effect coefficient estimates of the mixed models and their standard errors.

Data include both experimental setting 1 that used apoptotic MNC-secretomes derived from rats, “rMNC ^{apo sec}”, ( Table 1a), and setting 2 that used apoptotic MNC-secretomes derived from humans, “hMNC ^{apo sec}”, ( Table 1b). p-values are calculated from t-tests with the null hypothesis of the true coefficient being equal to 0. The factor Treatment was coded in a way that Treatment=0 corresponds to the control group and Treatment=1 corresponds to the treatment group. The time point 6 h is the reference group for the factor Time.

Table 1a: Linear mixed model analysis for setting 1. “rMNC apo sec”.
Effect	Estimate	Standard Error	p
Intercept	5	0.2502	<.0001
Time 24 h	0	0.2566	1
Time 48 h	-0.1875	0.2566	0.471
Treatment	-0.0625	0.3538	0.8611
Treatment*Time 24 h	-1.0625	0.3629	0.0067
Treatment*Time 48 h	-1.5625	0.3629	0.0002
Table 1b: Linear mixed model analysis for setting 2. “hMNC apo sec”.
Effect	Estimate	Standard Error	p
Intercept	4.5714	0.2761	<.0001
Time 24 h	0.1429	0.3442	0.6818
Time 48 h	-0.5	0.3442	0.1593
Treatment	0	0.3905	1
Treatment*Time 24 h	-1.4286	0.4868	0.0072
Treatment*Time 48 h	-1.6429	0.4868	0.0025