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. 2014 Aug 8;592(Pt 19):4329–4351. doi: 10.1113/jphysiol.2014.277715

Figure 2. PP-LFS elicits an mGluR2 receptor-dependent form of LTD in BLA principal neurons that was attenuated by an mGluR2/3 selective antagonist and mimicked by an mGluR2/3 agonist.

Figure 2

A, A PP-LFS at 1 Hz induced LTD (diamonds, n = 6) that was insensitive to the NMDAR antagonist, (R)-CPP (squares, n = 6). B, PP-LFS-induced LTD was markedly attenuated by the specific mGluR2/3 antagonist, LY341495 (100 nm, n = 6). C, PP-LFS-induced LTD was blocked by the non-selective mGluR1/5 and mGluR2/3 antagonist, MCCG (100 μm, n = 6). D, co-incubation with the positive allosteric modulator of mGluR2, LY487379 (30 μm), caused a 4-fold increase in the potency of the mGluR2/3 agonist LY379268 (40 μm, n = 5). Upper traces in A–D are representative EPSPs before and after PP-LFS for the treatment groups indicated.