Figure 6. The mGluR2/3-dependent depotentiation of 5× HFS-induced LTP was not mimicked by DREADD-induced postsynaptic Gαi activation.
A, application of the mGluR2/3 agonist, LY379268 (100 μm), 20 min after 5× 100 Hz stimulation depotentiated (n = 5, squares) LTP in BLA afferents (n = 6, diamonds). B, activation of postsynaptic DREADD hM4D (Gi) receptors in BLA principal neurons following bath application of the selective ligand, CNO (10 μm, n = 5), failed to mimic the LY379268-induced depotentiation of LTP. Upper traces in A and B are representative EPSPs evoked at time points 1, 2 and 3.