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. 2014 Aug 8;592(Pt 19):4329–4351. doi: 10.1113/jphysiol.2014.277715

Figure 7. Modulation of postsynaptic AC levels following DREADD receptor activation in BLA principal neurons bidirectionally regulates LTP induction.

Figure 7

A, bath application of CNO (10 μM) significantly attenuated the magnitude of LTP induced by 5× HFS in BLA principal neurons transfected with hM4D Gi-coupled DREADD receptors (n = 5, stars). B, conversely, bath application of CNO facilitated the induction of LTP by a sub-threshold stimulation protocol (2× HFS) in BLA principal neurons transfected with rM3D Gs-coupled DREADD receptors (n = 5, stars). Upper traces in A and B are representative EPSPs evoked before and after CNO application.