Figure 2. Increased sensitivity to and mortality from electrically induced seizures in Lmx1b^f/f/p mice.

A, mean seizure severity observed in female and male Lmx1b^f/f (female, black; male, grey) and Lmx1b^f/f/p (female, white; male, hatched) mice following seizure induction with 5, 10, 30 and 50 mA of current in Lmx1b^f/f and Lmx1b^f/f/p mice; n = 6 for each group at 10, 30 and 50 mA, except n = 4 for Lmx1b^f/f/p mice of each sex at 10 mA (6 male and 6 female mice were tested; 2 males and 2 females did not have seizures). The absence of black and grey bars at 5 mA indicates that none of the 12 Lmx1b^f/f mice tested at 5 mA had seizures. *P < 0.001 between sexes among genotype; #P < 0.001 between genotype among sexes. Error bars, ± SEM. B, percentage female and male Lmx1b^f/f (female, black; male, grey) and Lmx1b^f/f/p (female, white; male, hatched) mice still alive following seizures that were induced with 5, 10, 30 and 50 mA currents; n = 6 for each group at each intensity. *Logistic regression P-value < 0.05, between genotype and sexes within intensity. The absence of a hatched bar at 50 mA indicates that all six male Lmx1b^f/f/p died following seizure induction with 50 mA.