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. 2014 Oct 31;8:355. doi: 10.3389/fncel.2014.00355

Table 1.

Summary incidence table of lesions in control and STZ-induced diabetic rat cerebellum.

Control 2nd week 4th week 6th week 8th week 10th week 12th week
Ballooning of purkinje cell ++ ++ ++ ++ ++ ++
Chromatolysis ++ ++ +++ ++++ ++++ ++++
Vacuolation ++ ++ +++ +++ ++++
Necrosis/Apoptosis ++ ++ +++ +++ ++++ ++++
Pyknosis/Dark purkinje cell ++ ++ +++ +++ ++++ ++++
Gliosis + ++ ++ +++ ++++ ++++
Neuronophagia ++ ++ +++ ++++ ++++

−, Nil (less than 5%); +, minimal (5–10%); ++, mild (10–20%); +++, moderate (20–30%); ++++, severe (more than 30%).