Betaine supplementation had no effect on body weight change in C57BL/6 mice fed high-sucrose diet. A: changes of absolute body weight. C57BL/6 mice were fed with high-sucrose diet in the presence or absence of betaine supplementation (1%) in drinking water for 16 wk. Data are means ± SD (n = 8), *P < 0.05. SD, standard diet; HS, high-sucrose diet; BT, betaine. B: changes of body weight gain. C57BL/6 mice were fed with high-sucrose diet in the presence or absence of betaine supplementation (1%) in drinking water (n = 8 mice per group) for 16 wk. Data are means ± SD (n = 8), *P < 0.05.