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. Author manuscript; available in PMC: 2014 Oct 31.
Published in final edited form as: Am J Physiol Gastrointest Liver Physiol. 2007 Aug 16;293(4):G894–G902. doi: 10.1152/ajpgi.00133.2007

Fig. 6.

Fig. 6

Betaine supplementation suppressed high-sucrose feeding-induced gene expression of ACC (A), fatty acid synthase (FAS; B), and SREBP-1d (C) in the liver. Male C57BL/6 mice were fed with high-sucrose diet in the presence or absence of betaine supplementation (1%) in the drinking water for 16 wk. Total RNA from liver tissues were isolated thereafter and subjected to real-time RT-PCR assay to quantitate mRNAs for ACC, FAS, and SREBP-1c. HS significantly elevated expression of all 3 genes compared with the SD group. Supplementation with betaine suppressed the elevated expression of these genes induced by HS feeding. Data are means ± SD (n = 4). Bars with different letters differ significantly (P < 0.05).