Table 1.

Mean methylation fractions for BDNF CpG units in bipolar disorder versus controls

Amplicon	CpG unit	BP MMF (SD)	Controls MMF (SD)	Z	Asymp. sig.	Cohen's d
D2a	1, 2	0.354 (0.077)	0.335 (0.067)	−1.712	0.087
	11, 26	0.156 (0.025)	0.159 (0.038)	−0.061	0.951
	12, 13, 14	0.301 (0.030)	0.289 (0.034)	−1.864	0.062
	15	0.103 (0.022)	0.100 (0.026)	−0.682	0.495
	16	0.086 (0.012)	0.082 (0.015)	1.797	0.072
	17	0.122 (0.032)	0.116 (0.015)	−2.33	0.02*
	18, 19, 20	0.242 (0.032)	0.232 (0.035)	−1.789	0.072
	21	0.128 (0.014)	0.126 (0.023)	−0.449	0.654
	22, 23	0.275 (0.018)	0.260 (0.023)	−2.094	0.036*
	24	0.089 (0.011)	0.086 (0.028)	−1.217	0.224
	27, 28, 29, 30	0.246 (0.031)	0.238 (0.014)	−1.284	0.199
	3	0.355 (0.034)	0.333 (0.032)	−3.315	0.001 **	0.680
	4	0.054 (0.025)	0.048 (0.031)	−1.054	0.292
	5, 6	0.279 (0.047)	0.274 (0.022)	−0.733	0.464
	9, 10	0.254 (0.034)	0.255 (0.038)	−0.256	0.798
D3	11, 12, 13	0.227 (0.014)	0.217 (0.019)	−2.889	0.004 **	0.610
	14	0.085 (0.011)	0.079 (0.017)	−2.37	0.018*
	15, 16, 17	0.181 (0.016)	0.163 (0.027)	−2.993	0.003 **	0.840
	18	0.068 (0.012)	0.061 (0.011)	−3.179	0.001 **	0.610
	19	0.055 (0.011)	0.056 (0.012)	−0.157	0.875
	2, 3, 4	0.284 (0.019)	0.282 (0.020)	−0.484	0.628
	20	0.480 (0.068)	0.504 (0.101)	−0.728	0.466
	21	0.021 (0.008)	0.021 (0.015)	−0.728	0.466
	22, 23, 8	0.136 (0.008)	0.126 (0.014)	−3.8	<0.001 **	0.910
	5, 6	0.316 (0.029)	0.302 (0.054)	−0.601	0.548
	7	0.068 (0.011)	0.066 ()0.016	−0.799	0.424
	9, 10	0.069 (0.009)	0.066 (0.012)	−2.017	0.044*
D5	11, 12, 13	0.233 (0.030)	0.220	−1.962	0.05*
	14	0.065 (0.014)	0.063	−0.853	0.394
	15	0.253 (0.085)	0.253	−0.155	0.877
	16	0.093 (0.022)	0.083	−2.119	0.034*
	17, 18, 19	0.172 (0.017)	0.160	−2.447	0.014*
	4, 5	0.168 (0.097)	0.200	−1.09	0.276
	6	0.056 (0.017)	0.057	−0.391	0.696
	7, 8	0.205 (0.021)	0.197	1.671	0.095
	9	0.061 (0.048)	0.074	−1.35	0.177

*Significant at alpha = 0.05; **significant after FDR, alpha = 0.004; BP, bipolar disorder. MMF, mean methylation; d, effect size; Z, Mann Whitney U test statistic.