Table 4.

Estimated parameter coefficients and significance of 144 patients taking 207 antidepressants for 100 days ^a

Parameter	Coefficient estimate	95% Wald confidence interval	Wald chi-square	P
Total pill burden	0.009	(0.003, 0.015)	8.004	0.005*
Total number of medications	0.020	(0.006, 0.033)	7.857	0.005*
Percent days depressed	0.002	(<0.001, 0.003)	5.865	0.015*
Percent days euthymic	−0.001	(−0.003, <0.000)	3.891	0.049*
Percent days manic	0.000	(−0.004, 0.003)	0.065	0.799

^aGEE model estimated ApEn (1,0.2 × SD,100) using listed parameters with an independent correlation structure for each patient. Degrees of freedom were 1 for all models.

*Significant < 0.05.