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Trials of 2 nd generation TKI in acquired resistance setting
| N | OR% | mPFS (mo) | mOS (mo) | |
|---|---|---|---|---|
| Afatinib | ||||
| LUX LUNG I trial 40 | ||||
| Afatinib | 390 | 7 | 3.3 | 10.8 |
| Placebo | 195 | <1 | 1.1 | 12.0 |
| LUX LUNG IV trial 42 | 61 | 8.2 | 4.4 | 19 |
| XL647 | ||||
| Phase II trial52 | 41 | 3 | 3.6 | 16.1 |
<, less than.
