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. 2014 May 13;9(7):1536–1544. doi: 10.1021/cb5001586

Table 3. SAR of Pyridine Analogues with 2,4-Halide Substituted Phenyl Ring.

graphic file with name cb-2014-001586_0008.jpg

analog R1 R2 μM
3 2-Cl H 0.04 ± 0.01
30 2-CN F 0.11 ± 0.01
31 2-CF3 F 0.01 ± 0.001
32 2-Cl, 3-CF3 F 0.63 ± 0.05
33 2-CN Cl 0.29 ± 0.03
34 3-CN Cl 1.8 ± 0.34
35 5-Cl Cl 0.21 ± 0.03
36 2-Cl, 3-CF3 Cl 0.97 ± 0.46
a

Average of at least three replicates ± standard deviation.