Table 3. GeneMANIA network analyses reveals both overlapping and unique biological functions among GWA genes from MeHg alone and MeHg+caffeine.
| MeHg alone | MeHg + Caffeine | ||||||
| Function | FDR | Network | Genome | Function | FDR | Network | Genome |
| muscle organ development | 1.73E–11 | 24 | 247 | transmembrane receptor protein tyrosine kinase signaling | 3.40E–05 | 12 | 129 |
| muscle structure development | 1.73E–11 | 26 | 294 | enzyme linked receptor protein signaling pathway | 1.26E–04 | 13 | 187 |
| muscle cell differentiation | 3.38E–10 | 20 | 184 | muscle organ development | 3.04E–04 | 14 | 247 |
| striated muscle cell differentiation | 7.56E–09 | 18 | 170 | muscle structure development | 3.04E–04 | 15 | 294 |
| muscle tissue development | 7.58E–08 | 16 | 151 | regulation of cell differentiation | 9.79E–04 | 14 | 283 |
| striated muscle tissue development | 7.58E–08 | 16 | 150 | tissue morphogenesis | 1.05E–03 | 14 | 289 |
| skeletal muscle organ development | 7.58E–08 | 17 | 173 | protein phosphorylation | 1.53E–03 | 13 | 258 |
| visceral muscle development | 1.83E–07 | 7 | 14 | epithelium development | 3.80E–03 | 13 | 286 |
| skeletal muscle tissue development | 2.34E–07 | 15 | 141 | adult behavior | 3.80E–03 | 9 | 126 |
| urogenital system development | 1.00E–06 | 11 | 71 | genital disc development | 4.04E–03 | 6 | 44 |
| renal system development | 1.00E–06 | 11 | 71 | response to organic substance | 4.98E–03 | 12 | 261 |
| cell migration | 1.25E–06 | 17 | 217 | embryonic morphogenesis | 4.98E–03 | 11 | 213 |
| cell motility | 2.31E–06 | 17 | 227 | regulation of nervous system development | 4.98E–03 | 10 | 176 |
| localization of cell | 3.63E–06 | 17 | 235 | skeletal muscle organ development | 4.98E–03 | 10 | 173 |
| regulation of muscle tissue development | 4.45E–06 | 10 | 65 | regulation of cell development | 4.98E–03 | 11 | 217 |
| regulation of striated muscle tissue development | 4.45E–06 | 10 | 65 | neuromuscular junction development | 5.23E–03 | 8 | 106 |
| regulation of muscle organ development | 8.81E–06 | 10 | 70 | skeletal muscle fiber development | 5.64E–03 | 8 | 108 |
| tube development | 2.30E–05 | 13 | 149 | morphogenesis of an epithelium | 5.64E–03 | 12 | 269 |
| tissue migration | 3.42E–05 | 8 | 44 | muscle cell differentiation | 5.76E–03 | 10 | 184 |
| transmembrane receptor protein tyrosine kinase sig. | 3.51E–05 | 12 | 129 | muscle tissue development | 6.63E–03 | 9 | 151 |
| enzyme linked receptor protein signaling pathway | 4.00E–05 | 14 | 187 | striated muscle tissue development | 6.63E–03 | 9 | 150 |
| cell-cell adhesion | 7.98E–05 | 10 | 90 | synapse organization | 6.63E–03 | 9 | 149 |
| striated muscle cell development | 9.81E–05 | 12 | 144 | hindgut morphogenesis | 6.63E–03 | 6 | 55 |
| renal filtration cell differentiation | 9.81E–05 | 5 | 12 | muscle fiber development | 6.80E–03 | 8 | 116 |
GeneMANIA derived biological network integration results from MeHg and MeHg+caffeine GWA genes. Overlapping networks with muscle related function (bold text)and receptor signaling/tyrosine kinase function (italicized bold text) are indicated. Also shown are False discovery rate (FDR) and coverage indicated by the number of the genes in the ‘Network’ with a given function relative to all the genes in the ‘Genome’ identified with that function.