Table 4. MeHg: Muscle structure development network query genes.
Gene Name | Fly Base ID | No. SNPs | Gene Function | Protein Function | CG # | Human Homolog |
If | FBgn0001250 | 11 | Axon guidance, muscle attachment, myofibril assembly | integrin alpha chain | CG9623 | - |
kirre | FBgn0028369 | 1 | Myoblast fusion | immunoglobulin | CG3653 | Kirrel/NEPH1 |
Sff | FBgn0036544 | 1 | NMJ development | Protein serine/threonine kinase | CG6114 | - |
Rae1 | FBgn0034646 | 1 | Negative regulation of synaptic growth at NMJ | WD40 repeat | CG9862 | RAE1 |
Rols | FBgn0041096 | 1 | Myoblast fusion | zinc finger, ankyrin repeat | CG32096 | - |
Kon | FBgn0032683 | 1 | Muscle attachment, muscle organ development, neurogenesis | laminin G domain, concanavalin A-like lectin | CG10275 | CSPG4 |
pum | FBgn0003165 | 1 | Regulation of synaptic growth at NMJ, synaptic transmission, dendrite morphogenesis, pole cell migration | RNA binding protein | CG9755 | PUM1/PUM2 |
Msp-300 | FBgn0261836 | 1 | Skeletal muscle development, flight, locomotion | actin-binding, actinin-type, spectrin repeat | CG42768 | |
caup | FBgn0015919 | 1 | Muscle cell fate commitment | Tale/IRO homebox family | CG10605 | IRX3 |
spin | FBgn0086676 | 1 | Regulation of synaptic growth at NMJ, locomotion, nervous system remodeling, glial migration | unknown | CG8428 | SPNS1/2/3 |
ths | FBgn0033652 | 1 | Myoblast migration, heart development | FGF receptor binding, growth factor | CG12443 | - |
sns | FBgn0024189 | 1 | Myoblast fusion, nephrocyte diaphragm assembly | immunoglobulin | CG33141 | NPHS1 |
Sdc | FBgn0010415 | 1 | Regulation of synaptic growth at NMJ, motor neuron axon guidance | heparin sulfate proteoglycan, cytoskeletal binding | CG10497 | - |
numb | FBgn0002973 | 3 | Muscle cell fate specification, neurogenesis | Notch binding | CG3779 | NUMB/NUMBL |
MED4 | FBgn0035754 | 1 | Muscle organ development | RNA Pol II cofactor activity | CG8609 | MED4 |
Genes identified in the GWA for MeHg that constitute the “Muscle Structure Development” network are listed. The human homologs listed were identified in Flybase.