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Hydrophobic interaction chromatography analysis demonstrates the clean conversion of LC-, CH1-, and CT-tagged antibodies into homogeneous ADCs. Unconjugated antibody (black) elutes as one peak. After conjugation to HIPS-Glu-PEG2-maytansine, the ADC (green) elutes as a diconjugated material (right). This clean separation of conjugated from unconjugated material allows for conjugate enrichment and simple determination of DAR. α-HER2-DM1 was included as a comparator.
