Figure 8.

α-HER2 CT ADC is less toxic than the α-HER2-DM1 at the same doses in Sprague–Dawley rats. Animals (5/group) received a 6, 20, or 60 mg/kg dose of α-HER2 CT ADC (shown in blue) or α-HER2-DM1 (shown in red), followed by a 12 day observation period. Body weight (A) was monitored at the times indicated. Alanine aminotransferase (B), aspartate aminotransferase (C), and platelet counts (D) were assessed at day 5 postdose. Due to premature death (for 2 animals in the α-HER2-DM1 60 mg/kg group) or sample collection errors (platelet-specific, for animals in the vehicle control and both 6 mg/kg groups), some groups comprise fewer than 5 data points.