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Toxicokinetic analysis demonstrated that the α-HER2 CT ADC was more stable in rats than the α-HER2-DM1. The same animals that were analyzed for indicators of toxicity (Figure 8) were used to assess the toxicokinetic profiles of the α-HER2 CT ADC and α-HER2-DM1 analytes. Plasma was sampled at the time points indicated and assayed by ELISA.
