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. 2014 May 16;9(7):1632–1637. doi: 10.1021/cb500162w

Figure 2.

Figure 2

Aspirin does not inhibit amyloid formation by human amylin. (A) Thioflavin-T fluorescence assays of the time course of amyloid formation in the absence (black) and presence (red) of a 20-fold excess of aspirin. (B) TEM image of the sample of amylin without aspirin recorded at the end of the kinetic experiment. (C) TEM image of the sample of amylin with a 20-fold excess aspirin recorded at the end of the kinetic experiment. Scale bars represent 100 nm. Experiments were conducted at pH 7.4 and 25 °C in 20 mM Tris buffer with 0.25% DMSO (v/v) in the absence of any fluorinated alcohol cosolvent. The concentration of amylin was 16 μM, and the concentration of aspirin was 320 μM.