. Author manuscript; available in PMC: 2014 Oct 31.

Published in final edited form as: Eur J Med Chem. 2014 Mar 6;77:315–322. doi: 10.1016/j.ejmech.2014.03.009

Table 2.

Evaluation of 3a–d, g, 4a, c, e, g, i and 5 against some human tumor cell lines.^a

Compound	All cell lines, IC₅₀ (μM)^c	Colon cancer cells, IC₅₀ (μM)^b						Leukemic cells, IC₅₀ (μM)^b
Compound	All cell lines, IC₅₀ (μM)^c	COLO 205	HCC-2998	HCT-15	KM12	SW-620	Ave	HL-60 (TB)	K-562	RPMI-8226	SR	Ave
3a^a	0.31	0.36	0.19	0.30	0.04	0.07	0.19	0.20	0.20	0.03	0.02	0.11
3b	0.58	0.63	0.62	0.16	0.30	0.32	0.41	1.12	0.28	0.12	0.16	0.42
3c	0.22	0.16	0.31	0.14	0.21	0.18	0.20	0.19	0.13	0.05	0.02	0.10
3d	8.51	12.3	16.6	5.89	11.2	3.80	9.96	13.2	5.89	1.17	1.78	5.51
3g	0.06	0.07	0.10	0.07	0.06	0.03	0.07	0.07	0.03	0.02	0.02	0.04
4a^a	0.24	0.16	0.17	0.17	0.13	0.05	0.14	0.29	0.05	0.13	0.03	0.13
4c	0.09	0.08	0.13	0.06	0.16	0.03	0.09	0.11	0.03	0.02	0.01	0.04
4e	0.19	0.17	0.30	0.08	0.17	0.15	0.17	0.23	0.10	0.03	0.05	0.10
4g	0.05	0.06	0.10	0.03	0.04	0.05	0.06	0.04	0.03	0.05	0.01	0.03
4i	1.66	1.66	1.74	1.17	0.69	0.76	1.20	1.74	0.53	0.35	0.46	0.77
5	0.19	0.19	0.18	0.20	0.16	0.06	0.16	0.25	0.04	0.04	0.04	0.09
5-Fluorouracil	29.5	3.39	5.75	6.61	7.94	18.6	8.46	85.1	126	3.55	60.3	68.7
Melphalan	19.1	32.4	52.5	36.3	57.5	26.9	41.1	0.38	195	28.2	3.24	56.7

The data for 3a and 4a have been published previously [9].

The IC₅₀ values are the concentrations of the compounds which inhibit tumor cell growth by 50%.

As indicated in the experimental section, the IC₅₀ values of 3d and 5-fluorouracil towards a few cell lines were not generated due to their being somewhat refractory to the compounds.