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. 2014 Oct 31;9(10):e110737. doi: 10.1371/journal.pone.0110737

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© 2014 Tao et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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A control (dab2 heterozygous) and dab2 knockout (dab2 (f/df):Sox2-Cre) group of six 6-month old mice were mated, became pregnant, gave birth, and nursed an equal number (six) of pups per mouse. At day 12 of lactation, the mice underwent forced involution by removal of the pups. Mammary glands were harvested accordingly for histological analysis. Consistent results were obtained in two independent experiments using deletion by either Meox2-Cre or Sox2-Cre. (A) Representative H&E images show the morphology of the mammary glands. (B) Images of higher magnification are shown for day 3 and 5 of involution. Accumulating apoptotic cells in the lumen are indicated by a green arrow. (C) Mammary tissues of heterozygous and dab2 knockout at day 3 of forced involution were analyzed by transmission electron microscopy. An arrow indicates the presence of cells in the interior of the dab2 knockout mammary lumens.