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. 2014 Jun 18;35(11):2415–2424. doi: 10.1093/carcin/bgu137

Fig. 3.

Fig. 3.

RECQL4 depleted cells are moderately sensitive to γ-irradiation and show increased accumulation of 53BP1 foci. (A) Western blots showing the RECQL4 protein levels in scrambled and RECQL4 KD HeLa cells. (B) Survival efficiencies of HeLa scrambled and RECQL4 KD cells after different doses of γ-irradiation. The experiments were performed in triplicate and the error bars represent the standard deviation. (C) Graph showing the average number of 53BP1 foci/cell in HeLa scrambled and RECQL4 KD cells. Cells irradiated with 2 Gy of IR were allowed to recover for 1 and 12 h under normal growth conditions. Controls, CTR, represent un-irradiated cells. Representative images of 53BP1 foci in scrambled and RECQL4 KD cells at 12 h after irradiation are shown on right.