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. 2014 Sep 18;35(11):2526–2533. doi: 10.1093/carcin/bgu191

Table II.

Geometric means of nicotine metabolite ratios stratified by UGT2B10 genotype

UGT 2B10 genotype
Asp67Tyr variant (rs6175900) Splice variant (rs116294140) Both variants
Alla Alla AAs All
N Means (95% CI) N Means (95% CI) N Means (95% CI) Genetic scoreb N Means (95% CI)
Nicotine metabolism pathways
 N-glucuronidation
   Nicotine glucuronide/TNE GG 2028 0.039 (0.037–0.042) AA 1853 0.042 (0.038–0.045) 156 0.03 (0.024–0.039) 0 1664 0.047 (0.043–0.051)
GT 204 0.014 (0.01–0.021) CA 333 0.025 (0.016–0.04) 166 0.02 (0.013–0.02) 1 503 0.021 (0.018–0.024)
TTc 2 0.000 CCc 48 0.002 (0.001–0.003) 41 0.00 (0.001–0.003) 2c 67 0.000 (0-0)
P-value <0.0001 <0.0001 <0.0001 <0.0001
  N-oxidation
   Nicotine N-oxide/TNE GG 2032 0.054 (0.052–0.056) AA 1858 0.053 (0.051–0.055) 157 0.052 (0.046–0.058) 0 1668 0.054 (0.052–0.056)
GT 205 0.052 (0.044–0.061) CA 333 0.050 (0.041–0.063) 166 0.050 (0.044–0.056) 1 504 0.052 (0.048–0.055)
TTc 2 0.043 (0.041–0.044) CCc 48 0.060 (0.049–0.075) 41 0.056 (0.045–0.07) 2c 65 0.070 (0.046–0.106)
P-value 0.5978 0.2584 0.6361 0.2553
  C-oxidationd
  (Total 3-HCOT+total cotinine)/TNE GG 2032 0.726 (0.718–0.734) AA 1858 0.722 (0.713–0.73) 157 0.757 (0.729–0.784) 0 1668 0.720 (0.711–0.729)
GT 205 0.743 (0.703–0.782) CA 333 0.746 (0.695–0.797) 166 0.792 (0.765–0.819) 1 504 0.748 (0.731–0.764)
TTc 2 0.913 (0.894–0.932) CCc 48 0.777 (0.727–0.828) 41 0.826 (0.774–0.879) 2c 67 0.758 (0.66–0.856)
P-value 0.4112 0.5023 0.0334 0.0116
Measures of enzyme activity
 UGT2B10
  Nicotine glucuronide/ nicotine GG 2028 0.377 (0.344–0.414) AA 1853 0.39 (0.352–0.429) 156 0.31 (0.225–0.421) 0 1664 0.45 (0.402–0.496)
GT 204 0.126 (0.08–0.201) CA 333 0.23 (0.128–0.411) 166 0.19 (0.143–0.264) 1 503 0.19 (0.155–0.224)
TTc 2 0.00 CCc 48 0.01 (0.008–0.027) 41 0.02 (0.01–0.036) 2c 67 0.00 (0–0.001)
P-value <0.0001 <0.0001 <0.0001 <0.0001
  Cotinine glucuronide/ cotinine GG 2031 1.12 (1.07–1.17) AA 1857 1.28 (1.22–1.38) 157 1.10 (0.97–1.24)b 0 1668 1.38 (1.33–1.44)
GT 205 0.54 (0.43–0.68) CA 333 0.63 (0.5–0.80) 166 0.48 (0.42–0.54) 1 504 0.68 (0.63–0.73)
TTc 1 0.01 CCc 47 0.02 (0.02–0.03) 40 0.02 (0.02–0.03) 2c 65 0.01 (0.005–0.013)
P-value <0.0001 <0.0001 <0.0001 <0.0001
 CYP2A6
  Total 3-HCOT/total cotinine GG 2032 1.38 (1.34–1.43) AA 1858 1.33 (1.29–1.38) 157 1.65 (1.469–1.853) 0 1668 1.29 (1.24–1.34)
GT 205 1.84 (1.56–2.18) CA 333 1.63 (1.31–2.02) 166 2.24 (2.003–2.513) 1 504 1.78 (1.66–1.90)
TTc 2 4.06 (2.82–5.30) CCc 48 3.76 (3.03–4.67) 41 4.75 (3.794–5.952) 2c 67 3.09 (2.04–4.69)
P-value 0.0011 0.0006 <0.0001 <0.0001
  Total 3-HCOT/cotinine GG 2031 3.21 (3.10–3.32) AA 1857 3.23 (3.11–3.35) 157 3.78 (3.35–4.26) 0 1668 3.23 (3.10–3.37)
GT 205 3.35 (2.82–3.98) CA 333 2.90 (2.32–3.63) 166 3.64 (3.23–4.09) 1 504 3.19 (2.97–3.43)
TTc 1 5.35 CCc 47 3.72 (2.97–4.66) 40 4.52 (3.57–5.72) 2c 65 3.11 (2.01–4.81)
P-value 0.631 0.6264 0.2706 0.9452
 FMO3
  Nicotine-N-oxide/nicotine GG 2028 0.54 (0.52–0.56) AA 1853 0.52 (0.50–0.54) 156 0.55 (0.48–0.63) 0 1664 0.53 (0.51–0.56)
GT 204 0.54 (0.45–0.65) CA 333 0.50 (0.39–0.64) 166 0.67 (0.59–0.76) 1 503 0.51 (0.47–0.55)
TTc 2 1.03 (0.69–1.38) CCc 48 0.66 (0.52–0.85) 41 0.77 (0.6–0.97) 2c 67 0.71 (0.44–1.14)
P-value 0.933 0.7811 0.0235 0.287

aIncudes all five ethnic groups, values are adjusted for age, sex, creatinine (natural log), BMI (natural log), and race.

bGenetic score 0, rs61750900 GG and rs116294140 AA; score 1, rs61750900 GT or rs116294140 CA; score 2, rs61750900 TT or rs116294140 CC, or both rs61750900 GT and rs116294140 CA

cIf n < 10 the mean (minimum-maximum) are presented, not the geometric means and 95% CIs.

dArithmetic means are presented.