Table 3. False-positive report probability values for associations between SAD risk and I/D polymorphism.
| Significant association | OR (95%CI) | P a | Statistical powerb | Prior probability | ||||
| 0.25 | 0.1 | 0.01 | 0.001 | 0.0001 | ||||
| Overall analyses | ||||||||
| Allelic comparison (I vs D) | 1.09 (1.01, 1.17) | 0.030 | 1 | 0.049 | 0.133 | 0.628 | 0.945 | 0.994 |
| Additive model (II vs DD) | 1.17 (1.01, 1.34) | 0.030 | 1 | 0.065 | 0.173 | 0.698 | 0.959 | 0.996 |
| Dominant model (II+ID vs DD) | 1.16 (1.04, 1.29) | 0.008 | 1 | 0.018 | 0.053 | 0.379 | 0.860 | 0.984 |
| All in HWE | ||||||||
| Allelic comparison (I vs D) | 1.11 (1.03, 1.20) | 0.009 | 1 | 0.025 | 0.073 | 0.463 | 0.897 | 0.989 |
| Additive model (II vs DD) | 1.19 (1.02, 1.38) | 0.027 | 0.999 | 0.060 | 0.161 | 0.679 | 0.955 | 0.995 |
| Dominant model (II+ID vs DD) | 1.17 (1.05, 1.31) | 0.005 | 1 | 0.019 | 0.055 | 0.391 | 0.866 | 0.985 |
| English language article | ||||||||
| Dominant model (II+ID vs DD) | 1.14 (1.02, 1.27) | 0.018 | 1 | 0.050 | 0.135 | 0.633 | 0.946 | 0.994 |
| North European subgroup | ||||||||
| Allelic comparison (I vs D) | 1.11 (1.01, 1.21) | 0.033 | 1 | 0.050 | 0.138 | 0.637 | 0.947 | 0.994 |
| Additive model (II vs DD) | 1.24 (1.05, 1.48) | 0.012 | 0.983 | 0.050 | 0.136 | 0.634 | 0.946 | 0.994 |
| Dominant model (II+ID vs DD) | 1.22 (1.03, 1.45) | 0.022 | 0.990 | 0.068 | 0.179 | 0.706 | 0.960 | 0.996 |
| Low study quality subgroup | ||||||||
| Additive model (ID vs DD) | 1.25 (1.02, 1.54) | 0.034 | 0.957 | 0.102 | 0.253 | 0.789 | 0.974 | 0.997 |
| Dominant model (II+ID vs DD) | 1.25 (1.01, 1.55) | 0.038 | 0.952 | 0.117 | 0.284 | 0.814 | 0.978 | 0.998 |
| Small sample size subgroup | ||||||||
| Allelic comparison (I vs D) | 1.17 (1.03, 1.32) | 0.018 | 1 | 0.031 | 0.088 | 0.515 | 0.915 | 0.991 |
| Additive model (II vs DD) | 1.32 (1.04, 1.66) | 0.021 | 0.863 | 0.058 | 0.155 | 0.669 | 0.953 | 0.995 |
| Additive model (ID vs DD) | 1.28 (1.06, 1.55) | 0.011 | 0.948 | 0.035 | 0.098 | 0.545 | 0.924 | 0.992 |
| Dominant model (II+ID vs DD) | 1.29 (1.06, 1.56) | 0.010 | 0.940 | 0.027 | 0.076 | 0.476 | 0.902 | 0.989 |
| Non PB subgroup | ||||||||
| Additive model (ID vs DD) | 1.29 (1.11, 1.50) | 0.001 | 0.975 | 0.003 | 0.009 | 0.087 | 0.489 | 0.906 |
| Dominant model (II+ID vs DD) | 1.24 (1.01, 1.52) | 0.037 | 0.967 | 0.106 | 0.263 | 0.797 | 0.975 | 0.997 |
| Before 2003 subgroup | ||||||||
| Allelic comparison (I vs D) | 1.12 (1.01, 1.24) | 0.035 | 1 | 0.080 | 0.207 | 0.742 | 0.967 | 0.997 |
| Additive model (II vs DD) | 1.24 (1.01, 1.53) | 0.037 | 0.962 | 0.123 | 0.295 | 0.822 | 0.979 | 0.998 |
| Additive model (ID vs DD) | 1.30 (1.10, 1.54) | 0.002 | 0.951 | 0.008 | 0.022 | 0.200 | 0.716 | 0.962 |
| Dominant model (II+ID vs DD) | 1.28 (1.09, 1.52) | 0.003 | 0.965 | 0.015 | 0.043 | 0.333 | 0.835 | 0.981 |
| PCR (insertion-specific) subgroup | ||||||||
| Dominant model (II+ID vs DD) | 1.17 (1.01, 1.35) | 0.035 | 1 | 0.086 | 0.221 | 0.757 | 0.969 | 0.997 |
OR: odd ratio; CI: confidence interval.
a
p value for significant test; b Statistical power was calculated using the number of observations in the meta-analysis and the OR and p value in this table.
Bold values indicated that the prior probability <0.2.