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. 2014 Oct 31;9(10):e111351. doi: 10.1371/journal.pone.0111351

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© 2014 Chatterjee et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Real Time PCR analysis of the Aif1 gene expression showed that there is approximately four fold up regulation in RSA59 infected mice brain compared to mock infection (*Represents significant upregulation. P value of Aif1 <0.005) (A). Immunohistochemistry with anti Iba1 antibody showed a huge upregulation of microglia specific Iba1 protein expression in RSA59 infected brain section (C) compared to mock infected control (B). Higher magnification (1000x) of individual microglia in RSA59 infection showed the presence of large cell body and amoeboid processes (phagocytic in nature) (E). In resting control brain microglia has thin ramified processes and cell size in comparatively smaller. (D).