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. 2014 Oct 31;9(10):e111547. doi: 10.1371/journal.pone.0111547

Figure 5. The in vitro cumulative permeation profile of ibuprofen sodium across dermatomed 350 µm neonatal porcine skin when delivered using in-dwelling super swelling MN arrays combined with lyophilised drug reservoirs (Means ± S.D., n = 9) (A).

Figure 5

Digital images of the ibuprofen sodium-loaded lyophilised wafers used in in vitro and in vivo experiments and prepared from aqueous blends containing 10% w/w gelatin, 3% w/w mannitol and 40% w/w ibuprofen sodium (B, C). The in vitro cumulative permeation profile of OVA across dermatomed 350 µm neonatal porcine skin when delivered using in-dwelling super swelling MN arrays combined with lyophilised drug reservoirs (Means ± S.D., n = 5) (D). Digital images (E, F)of the OVA-loaded lyophilised wafers used in in vitro and in vivo experiments and prepared from aqueous blends containing 10% w/w gelatin, 40% w/w mannitol, 10% w/w NaCl, 1% w/w sucrose and 0.5% w/w OVA. These active-loaded tablets exhibited high porosities as exemplified in (G).