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. 2014 Oct 31;9(10):e111549. doi: 10.1371/journal.pone.0111549

Figure 7. Mouse BASIC is also affected by membrane active substances.

Figure 7

A) Representative current traces of mBASIC-expressing oocytes showing that the application of 2 mM UDCA, 500 µM CPZ, 10 mM TNP, 100 µM Triton-X 100, 500 µM NL or 400 µM SDS change the activity of mBASIC. Dotted lines represent the 0 current level. To evaluate the amiloride-sensitive current 100 µM amiloride (AMI) was applied after wash-out of the membrane active substances. (B) Quantitative comparison of current amplitudes induced by UDCA, CPZ, TNP, Triton-X 100, NL or SDS. Currents were normalized to the amiloride-sensitive current, which had an amplitude of 12.3±2.4 µA (n = 56). Error bars represent SEM. Statistical significances were tested using one-way ANOVA followed by Tukey's multiple comparison test versus control, *p<0.05, **p<0.01, ***p<0.001, n = 8.