Figure 2. Theoretical figure including atrophy which may play a role in delayed stimulation induced side effects.

Progressive 10%, 20%, 30%, and 40% atrophy with stimulation spread to other structures can be observed following columns to the right. DBS = Deep Brain Stimulation; Str = striatum; GPe = globus pallidus externus; GPi = globus pallidus internus; IC = internal capsule; Th = thalamus; STN = subthalamic nucleus; Vim = ventralis intermedius nucleus; RN = red nucleus; SNR = substantia nigra pars reticulata. This figure is theoretical and shows how atrophy may potentially affect lead location and stimulation fields.