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. 2014 Oct 31;9(10):e112519. doi: 10.1371/journal.pone.0112519

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© 2014 The PLOS ONE Staff

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Intracellular accumulation of tacrolimus (0.05 μM) after 15, 30 sec, 1, 5, 10, 30 or 60 min of efflux (N = 6) in (A) CTL HEK293, CTL HEKpcDNA3.1, HEK_1199G and HEK_1199A and (B) CTL K562, CTL K562pcDNA3.1, K562_1199G and K562_1199A. Cells were pre-loaded with tac for 120 min before efflux. The intracellular accumulation of Tac in each cell line was normalized by reporting the absolute amounts of Tac (in ng) on the total amount of proteins in cell extracts, expressed in mg. * compared to CTL pcDNA3.1 *p<0.05 **p<0.01 ***p<0.001.