Figure 1. Association of PEAR1 rs12041331 genotype with on-aspirin platelet aggregation assessed by multiple electrode aggregometry (Multiplate Analyzer) and VerifyNow Aspirin.

Comparisons of platelet aggregation levels across genotypes were adjusted for the following baseline variables and cardiovascular risk factors: Age, sex, smoking, body mass index, previous myocardial infarction, diabetes, proton pump inhibitor use, and platelet count. Patients homozygous for the A allele were pooled with heterozygotes for regression analysis. Horizontal lines and boxes indicate median with interquartile range. Whiskers indicate ±1.5 interquartile range and points beyond whiskers indicate outliers.